Myeloperoxidase G-463A polymorphism and coronary artery disease susceptibility in the Chinese population: an updated meta-analysis and review
نویسندگان
چکیده
Objective: Although a number of studies have been conducted on the association between myeloperoxidase (MPO) G-463A polymorphism and coronary artery disease (CAD), this association remains elusive and controversial. To assess the effects of MPO G-463A polymorphism on the risk of CAD in the Chinese population, an updated meta-analysis was performed. Methods: Related studies were identified from PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure (CNKI), and Chinese Biology Medicine (CBM) up to 28th March 2015. Pooled ORs and 95% CIs were used to assess the strength of the associations. Results: A total of ten studies including 1808 CAD cases and 1030 controls were involved in this meta-analysis. In overall analysis, MPO -436 A variant genotype reduces the risk of CAD in the Chinese population (A vs. G: OR = 0.53, 95% CI = 0.43-0.66; AA vs. GG: OR = 0.25, 95% CI = 0.15-0.40; AA vs. GA: OR = 0.45, 95% CI = 0.33-0.62; AA and GA combined vs. GG: OR = 0.51, 95% CI = 0.40-0.66; AA vs. GA and GG: OR = 0.34, 95% CI = 0.25-0.46). In subgroups stratified by geographical location and source of controls, significant associations were found in North China, in South China, in hospital-based studies and population-based studies. Conclusions: This meta-analysis showed that the MPO G-463A variants may influence CAD risk in Chinese. Studies with larger sample sizes and wider spectrum of populations are warranted to verify this finding.
منابع مشابه
APOA5 -1131T/C polymorphism and coronary artery disease susceptibility in Chinese population: an updated meta-analysis and review.
Although many studies have investigated the association of the APOA5 -1131T/C polymorphism with coronary artery disease (CAD), definite conclusions have not been drawn. To understand the effects of the APOA5 -1131T/C polymorphism on the risk of developing CAD, we performed an updated meta-analysis in the Chinese population. Relevant studies published till April 2015 were identified from databas...
متن کاملAssociation of Myeloperoxidase -463 G/A Polymorphism with Clinical Outcome of Helicobacter Pylori infection in Iranian Patients with Gastrointestinal Diseases
Background: Polymorphisms in the immune related genes are important in the clinical outcome of Helicobacter pylori infection. Myeloperoxidase -463 G/A polymorphism has been shown to reduce enzyme expression and activity. Objective: the aim of the present study is to investigate the association of myeloperoxidase G-463A polymor-phism with clinical outcome of Helicobacter pylori infection. Method...
متن کاملStudying the Association between STAT4 Gene Polymorphism and Susceptibility to Rheumatoid Arthritis Disease: An Updated Meta-Analysis
متن کامل
Association of the G-463A myeloperoxidase polymorphism with infection in sickle cell anemia.
Infections constitute a principal cause of morbidity and mortality in sickle cell anemia (SCA). Here we present evidence to suggest that a polymorphism (G-463A MPO) in the gene encoding the myeloperoxidase (MPO) enzyme, important for the host defense system, may significantly increase susceptibility to infection in SCA.
متن کاملAssociation between Tumor Necrosis Factor- α-308 G/A Polymorphism and Multiple Sclerosis: A Systematic Review and Meta-Analysis
Multiple sclerosis (MS) is a complex polygenic disease in which gene-environment interactions are important. A number of studies have investigated the association between tumor necrosis factor-α (TNF-α) -308 G/A polymorphism (substitution G→A, designated as TNF1 and TNF2) and MS susceptibility in different populations, but the results of individual studies have been inconsistent. Therefore, per...
متن کامل